Kamis, 19 Mei 2016

The Cutter Incident: How America's First Polio Vaccine Led to the Growing Vaccine Crisis

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The Cutter Incident: How America's First Polio Vaccine Led to the Growing Vaccine Crisis Description

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Vaccines have saved more lives than any other single medical advance. Yet today only four companies make vaccines, and there is a growing crisis in vaccine availability. Why has this happened? This remarkable book recounts for the first time a devastating episode in 1955 at Cutter Laboratories in Berkeley, California, thathas led many pharmaceutical companies to abandon vaccine manufacture.

Drawing on interviews with public health officials, pharmaceutical company executives, attorneys, Cutter employees, and victims of the vaccine, as well as on previously unavailable archives, Dr. Paul Offit offers a full account of the Cutter disaster. He describes the nation’s relief when the polio vaccine was developed by Jonas Salk in 1955, the production of the vaccine at industrial facilities such as the one operated by Cutter, and the tragedy that occurred when 200,000 people were inadvertently injected with live virulent polio virus: 70,000 became ill, 200 were permanently paralyzed, and 10 died. Dr. Offit also explores how, as a consequence of the tragedy, one jury’s verdict set in motion events that eventually suppressed the production of vaccines already licensed and deterred the development of new vaccines that hold the promise of preventing other fatal diseases.

Vaccines have saved more lives than any other single medical advance. Yet today only four companies make vaccines, and there is a growing crisis in vaccine availability. Why has this happened? This remarkable book recounts for the first time a devastating episode in 1955 at Cutter Laboratories in Berkeley, California, thathas led many pharmaceutical companies to abandon vaccine manufacture.

Drawing on interviews with public health officials, pharmaceutical company executives, attorneys, Cutter employees, and victims of the vaccine, as well as on previously unavailable archives, Dr. Paul Offit offers a full account of the Cutter disaster. He describes the nation’s relief when the polio vaccine was developed by Jonas Salk in 1955, the production of the vaccine at industrial facilities such as the one operated by Cutter, and the tragedy that occurred when 200,000 people were inadvertently injected with live virulent polio virus: 70,000 became ill, 200 were permanently paralyzed, and 10 died. Dr. Offit also explores how, as a consequence of the tragedy, one jury’s verdict set in motion events that eventually suppressed the production of vaccines already licensed and deterred the development of new vaccines that hold the promise of preventing other fatal diseases.

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David Busch's Sony Alpha a6300/ILCE-6300 Guide to Digital Photography

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David Busch's Sony Alpha a6300/ILCE-6300 Guide to Digital Photography Info

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David Busch’s Sony Alpha a6300/ILCE-6300 Guide to Digital Photography is the most comprehensive reference and guide book available for Sony’s advanced APS-C mirrorless camera. This eagerly-anticipated enthusiast/professional digital camera features a new 24 megapixel sensor with 425 embedded phase-detect pixels for lightning-fast autofocus at up to 11 frames per second. With an electronic shutter that provides a silent shooting option, stunning 4K/UHD video capabilities, and ISO sensitivities up to ISO 51,200, the a6300/ILCE-6300 is a versatile digital camera that’s simple to use, yet boasts features demanded by the most avid photo buff. With this book in hand, you will discover all the capabilities of the Sony Alpha a6300/ILCE-6300 as you explore the world of digital photography, develop your creativity, and capture the best photographs you’ve ever taken.
Filled with detailed how-to steps and full-color illustrations, David Busch’s Sony Alpha a6300/ILCE-6300 Guide to Digital Photography describes every feature of this sophisticated camera in depth, from taking your first photos through advanced details of setup, exposure, lens selection, lighting, and more. It relates each feature to specific photographic techniques and situations. Also included is the handy camera “roadmap,” an easy-to-use visual guide to the a6300/ILCE-6300’s features and controls. Learn when to use every option and, more importantly, when not to use them, by following the author’s recommended settings for every menu entry. With best-selling photographer and mentor David Busch as your guide, you’ll quickly have full creative mastery of your camera’s capabilities, whether you’re shooting on the job, taking pictures as an advanced enthusiast pushing the limits of your imagination, or are just out for fun. Start building your knowledge and confidence, while bringing your vision to light with the Sony Alpha a6300/ILCE-6300..

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Rabu, 18 Mei 2016

The Expressiveness of the Body and the Divergence of Greek and Chinese Medicine

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At the heart of medical history is a deep enigma.The true structure and workings of the human body are, we casually assume, everywhere the same, a universal reality. But then we look into the past, and our sense of reality wavers: accounts of the body in diverse medical traditions often seem to describe mutually alien, almost unrelated worlds.The Expressiveness of the Body meditates on the contrasts between the human body described in classical Greek medicine and the body as envisaged by physicians in ancient China. It asks how this most basic of human realities came to be conceived by two sophisticated civilizations in radically diverging ways. And it seeks answers in fresh and unexpected topics, such as the history of tactile knowledge, the relationship between ways of seeing and ways of listening, and the evolution of bloodletting.

What are our bodies trying to tell us? In the scholarly yet delicately beautiful The Expressiveness of the Body, Japanese scholar Shigehisa Kuriyama examines two widely divergent traditions of diagnostic examination: Greek and Chinese. While at first glance it would seem that this would entail a straightforward familiar vs. exotic dichotomy for Western readers, only a short way into the book we realize that the ancient Greeks were just as foreign to us as the ancient Chinese. While there is some greater resemblance to modern medicine in the works of Galen and his contemporaries, Kuriyama shows us that their struggle to "decode" the body's signals was just as arbitrary--and just as accurate--as works like the Huangdi Neijing.

Showing that the often dramatic differences between their attitudes about signs such as pulse, breath, and blood both developed from and informed deeper beliefs about the nature of the body, Kuriyama exposes the highly subjective artistry of medicine. Like the proverbial blind men feeling the different parts of the elephant, the ancients focused exclusively on one set of traits and signs and developed a complex theoretical framework around it. Well documented and handsomely illustrated, The Expressiveness of the Body pokes and prods into the space between precise anatomical knowledge and the understanding of qi flow to find the rest of the elephant beyond the trunk, legs, and tail. --Rob Lightner.

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Top Dog: The Science of Winning and Losing

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Top Dog: The Science of Winning and Losing Info

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New York Times Bestseller

Po Bronson and Ashley Merryman's work changes the national dialogue. Beyond their bestselling books, you know them from commentary and features in the New York Times, CNN, NPR, Time, Newsweek, Wired, New York, and more. E-mail, Facebook, and Twitter accounts are filled with demands to read their reporting (such as "How Not to Talk to Your Kids," "Creativity Crisis," and "Losing Is Good for You").


In TOP DOG, Bronson and Merryman again use their astonishing blend of science and storytelling to reveal what's truly in the heart of a champion. The joy of victory and the character-building agony of defeat. Testosterone and the neuroscience of mistakes. Why rivals motivate. How home field advantage gets you a raise. What teamwork really requires. It's baseball, the SAT, sales contests, and Linux. How before da Vinci and FedEx were innovators, first, they were great competitors.

Olympians carry TOP DOG in their gym bags. It's in briefcases of Wall Street traders and Madison Avenue madmen. Risk takers from Silicon Valley to Vegas race to implement its ideas, as educators debate it in halls of academia. Now see for yourself what this game-changing talk is all about.

Q&A with Po Bronson and Ashley Merryman

Po Bronson and Ashley Merryman

Q. Are you refuting the concept that it takes ten years of practice to get great at anything?

Po Bronson: Not at all, we feel our book is additive to that story. Nobody is judged on how they practice. They're judged on how they perform when it counts. Practicing is not the same as competing. You can pitch a million baseballs to your son until he perfects his swing--but wait until he faces a pitcher who wants him to miss. You might have ten years of experience in the advertising industry, but how do you handle the day your biggest client tells you they're leaving for a rival agency?

Ashley Merryman: The truth is, nobody puts in ten years before they start competing. The world doesn't work that way. We are all thrown into competitive situations, long before we've had enough practice. Our results are still judged; our fate is still determined by how we do. To survive these trials, we need more than practice. We need competitive fire.

Q. Did researching this book change how you each compete?

Ashley Merryman: I'm a girl. All my life, I've been told to "play nice." I heard it on the playground and then the grown-up version they say in boardrooms: women are better at coalition-building, not competing. The science says that's wrong. And it's not just about toughening up. Women are prone to weigh risks more carefully than men; when women are confident they have a good chance to succeed, they'll compete. Sometimes this is an asset (in certain domains), but sometimes it's a hindrance. I've learned to recognize when to tap into my gender's knack for risk-analysis, and when to ignore it.

Po Bronson: I didn't let many people know it, but before working on this book, I'd had a full-hip replacement and a few unsuccessful surgeries on my leg. I had many setbacks during rehab; I could barely walk at times. This affected every dimension of my life--it sapped my energy for my writing work and my volunteer projects. I was just losing my edge and my will to fight. Researching the book inspired me; it reminded me who I am. It restored my zeal for attacking big challenges. I hope the book does that for readers, first and foremost: gets them eager to surmount the challenges in their lives.

Q. Everyone says that companies must innovate to remain competitive--but does it work the other way around? Doesn't competition destroy creativity?

Po Bronson: There is a belief that creative genius is fragile and needs to be shielded from competition and comparison. But the research says that's a myth. Leonardo da Vinci loved to have his art put side by side with the work of others for debate over whose was best; Bach, too, liked to compete against other musicians in public concerts. Chemical fire extinguishers, food canning, transcontinental air travel--each began as the prize winner of a competition. Competition doesn't kill creativity: it facilitates creative output by supplying motivational drive.

Ashley Merryman: Whether professional musicians or school children, studies have shown competition fuels creativity and even improves the quality of the work produced. More than that, the skills that make you a great competitor--such as a willingness to push boundaries, trust one's instincts, problem-solve--those are the same skills needed for innovation.

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Selasa, 17 Mei 2016

Executive Toughness: The Mental-Training Program to Increase Your Leadership Performance

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Executive Toughness: The Mental-Training Program to Increase Your Leadership Performance Info

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Take your professional game to the next level-in 100 seconds or less!

People with inborn talent may be good at what they do-but only the mentally tough reach the highest plateaus in their field. And here's the best news of all: mental toughness is something anyone can learn.

Director of mental training for the St. Louis Cardinals and a top-tier executive coach, Dr. Jason Selk knows everything there is to know about developing the mental toughness required for achieving any goal you set for yourself. In fact, the techniques he outlines in this book are the same ones he used to help the Cardinals defeat the heavily favored Detroit Tigers in the 2006 World Series.

Inspired on the vision of legendary basketball coach John Wooden, Selk's program is as simple as it is effective. But that doesn't mean it's easy. You have to put effort into your drive to success; it's the only way to build up your mental "muscles." Selk provides hands-on daily exercises for breaking old, self-defeating patterns of behavior and replacing them with the can-do attitude and positive behavior that would make Coach Wooden proud.

Executive Toughness outlines the three fundamentals for attaining high-level success:

ACCOUNTABILITY - admit to mistakes, correct them, and, most important, learn from them

FOCUS - on your strengths, on winning, on reaching your goal . . . for only 100 seconds per day

OPTIMISM - don't just believe you can succeed, know you can succeed

Executive Toughness takes you through the steps of making these critical behaviors part of your everyday routine. Practice your accountability, focus, and optimism, and you'll be on the path to attaining your goals; make them part of your mental "DNA," and there will be no turning back-ever.

A complete regimen from a leading expert on developing the mindset for attaining goals, Executive Toughness is your workout for ultimate success in your career and in your life.

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Senin, 16 Mei 2016

Eccentric Orbits: The Iridium Story

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Eccentric Orbits: The Iridium Story Description

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In the early 1990s, Motorola, the legendary American technology company developed a revolutionary satellite system called Iridium that promised to be its crowning achievement. Light years ahead of anything previously put into space, and built on technology developed for Ronald Reagan’s “Star Wars,” Iridium’s constellation of 66 satellites in polar orbit meant that no matter where you were on Earth, at least one satellite was always overhead, and you could call Tibet from Fiji without a delay and without your call ever touching a wire.

Iridium the satellite system was a mind-boggling technical accomplishment, surely the future of communication. The only problem was that Iridium the company was a commercial disaster. Only months after launching service, it was billion in debt, burning through 0 million a month and crippled by baroque rate plans and agreements that forced calls through Moscow, Beijing, Fucino, Italy, and elsewhere. Bankruptcy was inevitable—the largest to that point in American history. And when no real buyers seemed to materialize, it looked like Iridium would go down as just a “science experiment.”

That is, until Dan Colussy got a wild idea. Colussy, a former head of Pan-Am now retired and working on his golf game in Palm Beach, heard about Motorola’s plans to “de-orbit” the system and decided he would buy Iridium and somehow turn around one of the biggest blunders in the history of business.

In Eccentric Orbits, John Bloom masterfully traces the conception, development, and launching of Iridium and Colussy’s tireless efforts to stop it from being destroyed, from meetings with his motley investor group, to the Clinton White House, to the Pentagon, to the hunt for customers in special ops, shipping, aviation, mining, search and rescue—anyone who would need a durable phone at the end of the Earth. Impeccably researched and wonderfully told, Eccentric Orbits is a rollicking, unforgettable tale of technological achievement, business failure, the military-industrial complex, and one of the greatest deals of all time.
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Minggu, 15 Mei 2016

The Retirement Savings Time Bomb . . . and How to Defuse It: A Five-Step Action Plan for Protecting Your IRAs, 401(k)s, and Other Retirement Plans from Near Annihilation by the Taxman

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The Retirement Savings Time Bomb . . . and How to Defuse It: A Five-Step Action Plan for Protecting Your IRAs, 401(k)s, and Other Retirement Plans from Near Annihilation by the Taxman Info

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The premier guide for retirement and investment planning by "America's IRA Expert" (Mutual Funds magazine)-fully updated to reflect the recent tax rule changes

With the possible e xception of home property, the most valuable asset for most Americans is their retirement fund. Yet most people don't know that the IRS is waiting to grab up to 90 percent of their hard-earned retirement savings. Now, in this fully updated edition of The Retirement Savings Time Bomb, renowned tax advisor Ed Slott explains in clear-cut layman's terms what people need to know to keep their money and pass it on to their families..

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